diff --git a/proton b/proton
index 51991555..a84dd731 100755
--- a/proton
+++ b/proton
@@ -68,8 +68,14 @@ def append_to_env_str(env, variable, append_str, separator):
         env[variable] = env[variable] + separator + append_str
 
 def log(msg):
-    sys.stderr.write(PFX + msg + os.linesep)
-    sys.stderr.flush()
+    try:
+        sys.stderr.write(PFX + msg + os.linesep)
+        sys.stderr.flush()
+    except OSError:
+        # e.g. see https://github.com/ValveSoftware/Proton/issues/6277
+        # There's not much we can usefully do about this: printing a
+        # warning to stderr isn't going to work any better the second time
+        pass
 
 def file_is_wine_builtin_dll(path):
     if os.path.islink(path):