diff --git a/default_pfx.py b/default_pfx.py
index 89857366..4562b6ec 100755
--- a/default_pfx.py
+++ b/default_pfx.py
@@ -6,6 +6,7 @@
 
 import os
 import subprocess
+import re
 
 def file_is_wine_builtin_dll(path):
     if not os.path.exists(path):
@@ -71,6 +72,43 @@ def setup_dll_symlinks(default_pfx_dir, dist_dir):
                 os.unlink(filename)
                 make_relative_symlink(target, filename)
 
+KEY_RE = re.compile(r'\[(.+)\] ([0-9]+)')
+VALUE_RE = re.compile(r'"(.*)"="(.+)"')
+
+def filter_registry(filename):
+    """Remove registry values that contain a fully qualified path
+    inside some well-known registry keys. These paths are devised on
+    the build machine and it makes no sense to distribute them. Plus,
+    they are known to cause bugs."""
+
+    FILTER_KEYS = [
+        r'Software\\Microsoft\\Windows\\CurrentVersion\\Fonts',
+        r'Software\\Microsoft\\Windows NT\\CurrentVersion\\Fonts',
+        r'Software\\Wine\\Fonts\\External Fonts',
+    ]
+
+    filtering = False
+    with open(filename) as fin:
+        with open(filename + '.tmp', 'w') as fout:
+            for line in fin:
+                line = line.strip()
+
+                match = KEY_RE.match(line)
+                if match is not None:
+                    fout.write(line + '\n')
+                    filtering = match.group(1) in FILTER_KEYS
+                    continue
+
+                match = VALUE_RE.match(line)
+                if match is not None:
+                    if not filtering or match.group(2)[1:2] != ':':
+                        fout.write(line + '\n')
+                    continue
+
+                fout.write(line + '\n')
+
+    os.rename(filename + '.tmp', filename)
+
 def make_default_pfx(default_pfx_dir, dist_dir, runtime):
     local_env = dict(os.environ)
 
@@ -95,6 +133,9 @@ def make_default_pfx(default_pfx_dir, dist_dir, runtime):
         env=local_env, check=True)
     setup_dll_symlinks(default_pfx_dir, dist_dir)
 
+    filter_registry(os.path.join(default_pfx_dir, 'user.reg'))
+    filter_registry(os.path.join(default_pfx_dir, 'system.reg'))
+
 if __name__ == '__main__':
     import sys
     if len(sys.argv) > 3: